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Can Pure Predictions of Activity Coefficients from PC-SAFT Assist Drug–Polymer Compatibility Screening?

[Image: see text] The bioavailability of poorly water-soluble active pharmaceutical ingredients (APIs) can be improved via the formulation of an amorphous solid dispersion (ASD), where the API is incorporated into a suitable polymeric carrier. Optimal carriers that exhibit good compatibility (i.e.,...

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Detalles Bibliográficos
Autores principales: Pavliš, Jáchym, Mathers, Alex, Fulem, Michal, Klajmon, Martin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10410664/
https://www.ncbi.nlm.nih.gov/pubmed/37386723
http://dx.doi.org/10.1021/acs.molpharmaceut.3c00124