Cargando…
Structural basis for binding of Drosophila Smaug to the GPCR Smoothened and to the germline inducer Oskar
Drosophila Smaug and its orthologs comprise a family of mRNA repressor proteins that exhibit various functions during animal development. Smaug proteins contain a characteristic RNA-binding sterile-α motif (SAM) domain and a conserved but uncharacterized N-terminal domain (NTD). Here, we resolved th...
Autores principales: | Kubíková, Jana, Ubartaitė, Gabrielė, Metz, Jutta, Jeske, Mandy |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
National Academy of Sciences
2023
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10410706/ https://www.ncbi.nlm.nih.gov/pubmed/37523566 http://dx.doi.org/10.1073/pnas.2304385120 |
Ejemplares similares
-
RNA binding proteins Smaug and Cup induce CCR4–NOT-dependent deadenylation of the nanos mRNA in a reconstituted system
por: Pekovic, Filip, et al.
Publicado: (2023) -
Smaug regulates germ plasm synthesis and primordial germ cell number in Drosophila embryos by repressing the oskar and bruno 1 mRNAs
por: Siddiqui, Najeeb U., et al.
Publicado: (2023) -
Compartmentalized oskar degradation in the germ plasm safeguards germline development
por: Eichler, Catherine E, et al.
Publicado: (2020) -
High hedgehog signaling is transduced by a multikinase-dependent switch controlling the apico-basal distribution of the GPCR smoothened
por: Gonçalves Antunes, Marina, et al.
Publicado: (2022) -
Global regulation of mRNA translation and stability in the early Drosophila embryo by the Smaug RNA-binding protein
por: Chen, Linan, et al.
Publicado: (2014)