Polymorphic variants at NDUFC2, encoding a mitochondrial complex I subunit, associate with cardiac hypertrophy in human hypertension

BACKGROUND: A dysfunction of NADH dehydrogenase, the mitochondrial Complex I (CI), associated with the development of left ventricular hypertrophy (LVH) in previous experimental studies. A deficiency of Ndufc2 (subunit of CI) impairs CI activity causing severe mitochondrial dysfunction. The T allele...

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Detalles Bibliográficos
Autores principales: Gallo, Giovanna, Forte, Maurizio, Cotugno, Maria, Marchitti, Simona, Stanzione, Rosita, Tocci, Giuliano, Bianchi, Franca, Palmerio, Silvia, Scioli, Mariarosaria, Frati, Giacomo, Sciarretta, Sebastiano, Barbato, Emanuele, Volpe, Massimo, Rubattu, Speranza
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10410816/
https://www.ncbi.nlm.nih.gov/pubmed/37558995
http://dx.doi.org/10.1186/s10020-023-00701-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10410816/
https://www.ncbi.nlm.nih.gov/pubmed/37558995
http://dx.doi.org/10.1186/s10020-023-00701-x

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