Protease XIV abolishes NHE inhibition by empagliflozin in cardiac cells

Background: SGLT2i directly inhibit the cardiac sodium-hydrogen exchanger-1 (NHE1) in isolated ventricular cardiomyocytes (CMs). However, other studies with SGLT2i have yielded conflicting results. This may be explained by methodological factors including cell isolation techniques, cell types and am...

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Detalles Bibliográficos
Autores principales: Chen, Sha, Schumacher, Cees A., Van Amersfoorth, Shirley C. M., Fiolet, Jan W. T., Baartscheer, Antonius, Veldkamp, Marieke W., Coronel, Ruben, Zuurbier, Coert J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10410854/
https://www.ncbi.nlm.nih.gov/pubmed/37565139
http://dx.doi.org/10.3389/fphys.2023.1179131

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10410854/
https://www.ncbi.nlm.nih.gov/pubmed/37565139
http://dx.doi.org/10.3389/fphys.2023.1179131

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