Cargando…

A data-driven machine learning approach for discovering potent LasR inhibitors

The rampant spread of multidrug-resistant Pseudomonas aeruginosa strains severely threatens global health. This severity is compounded against the backdrop of a stagnating antibiotics development pipeline. Moreover, with many promising therapeutics falling short of expectations in clinical trials, t...

Descripción completa

Detalles Bibliográficos
Autores principales:	Koh, Christabel Ming Ming, Ping, Lilian Siaw Yung, Xuan, Christopher Ha Heng, Theng, Lau Bee, San, Hwang Siaw, Palombo, Enzo A., Wezen, Xavier Chee
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10411317/ https://www.ncbi.nlm.nih.gov/pubmed/37552115 http://dx.doi.org/10.1080/21655979.2023.2243416

Ejemplares similares

Identification of Potential p38γ Inhibitors via In Silico Screening, In Vitro Bioassay and Molecular Dynamics Simulation Studies
por: Cheng, Zixuan, et al.
Publicado: (2023)

Characterization of lasR-deficient clinical isolates of Pseudomonas aeruginosa
por: Wang, Yao, et al.
Publicado: (2018)

Kinetic Model for Signal Binding to the Quorum Sensing Regulator LasR
por: Claussen, Anetta, et al.
Publicado: (2013)

Isolation of the Autoinducer-Quenching Strain that Inhibits LasR in Pseudomonas aeruginosa
por: Weng, Lixing, et al.
Publicado: (2014)

Sulfane Sulfur Regulates LasR-Mediated Quorum Sensing and Virulence in Pseudomonas aeruginosa PAO1
por: Xuan, Guanhua, et al.
Publicado: (2021)

Reversible Signal Binding by the Pseudomonas aeruginosa Quorum-Sensing Signal Receptor LasR
por: Sappington, Kaia J., et al.
Publicado: (2011)

Study on pyoverdine and biofilm production with detection of LasR gene in MDR Pseudomonas aeruginosa
por: Hamza, Esraa H., et al.
Publicado: (2023)

Biofilm production by clinical isolates of Pseudomonas aeruginosa and structural changes in LasR protein of isolates non biofilm-producing
por: Lima, Jailton Lobo da Costa, et al.
Publicado: (2018)

A New Transcriptional Repressor of the Pseudomonas aeruginosa Quorum Sensing Receptor Gene lasR
por: Longo, Francesca, et al.
Publicado: (2013)

Stationary Phase-Specific Virulence Factor Overproduction by a lasR Mutant of Pseudomonas aeruginosa
por: Cabeen, Matthew T.
Publicado: (2014)

Virtual Screening of FDA-Approved Drugs against LasR of Pseudomonas aeruginosa for Antibiofilm Potential
por: Sadiq, Suhaib, et al.
Publicado: (2020)

Citrate cross-feeding between Pseudomonas aerguinosa genotypes supports lasR mutant fitness
por: Mould, Dallas L., et al.
Publicado: (2023)

Citrate cross-feeding between Pseudomonas aerguinosa genotypes supports lasR mutant fitness
por: Mould, Dallas L., et al.
Publicado: (2023)

Evolution of lasR mutants in polymorphic Pseudomonas aeruginosa populations facilitates chronic infection of the lung
por: Zhao, Kelei, et al.
Publicado: (2023)

Cystic fibrosis–adapted Pseudomonas aeruginosa quorum sensing lasR mutants cause hyperinflammatory responses
por: LaFayette, Shantelle L., et al.
Publicado: (2015)

LasR Variant Cystic Fibrosis Isolates Reveal an Adaptable Quorum-Sensing Hierarchy in Pseudomonas aeruginosa
por: Feltner, John B., et al.
Publicado: (2016)

Evolution of biofilm-adapted gene expression profiles in lasR-deficient clinical Pseudomonas aeruginosa isolates
por: Jeske, Alexander, et al.
Publicado: (2022)

High-Throughput Virtual Screening for a New Class of Antagonist Targeting LasR of Pseudomonas aeruginosa
por: Vetrivel, Aishwarya, et al.
Publicado: (2021)

LasR-regulated proteases in acute vs. chronic lung infection: a double-edged sword
por: Hennemann, Lisa C., et al.
Publicado: (2021)

Exemplifying the next generation of antibiotic susceptibility intensifiers of phytochemicals by LasR-mediated quorum sensing inhibition
por: Shukla, Arpit, et al.
Publicado: (2021)

Rise in frequency of lasR mutant Pseudomonas aeruginosa among keratitis isolates between 1993 and 2021
por: Shanks, Robert M. Q., et al.
Publicado: (2023)

Environmentally Endemic Pseudomonas aeruginosa Strains with Mutations in lasR Are Associated with Increased Disease Severity in Corneal Ulcers
por: Hammond, John H., et al.
Publicado: (2016)

A rise in the frequency of lasR mutant Pseudomonas aeruginosa among keratitis isolates between 1993 and 2021
por: Shanks, Robert M. Q., et al.
Publicado: (2023)

The phage-encoded protein PIT2 impacts Pseudomonas aeruginosa quorum sensing by direct interaction with LasR
por: Schroven, Kaat, et al.
Publicado: (2023)

Candida albicans-produced farnesol stimulates Pseudomonas quinolone signal production in LasR-defective Pseudomonas aeruginosa strains
por: Cugini, Carla, et al.
Publicado: (2010)

Microevolution of the mexT and lasR Reinforces the Bias of Quorum Sensing System in Laboratory Strains of Pseudomonas aeruginosa PAO1
por: Liu, Yang, et al.
Publicado: (2022)

In Silico Identification of Natural Food Compounds as Potential Quorum-Sensing Inhibitors Targeting the LasR Receptor of Pseudomonas aeruginosa
por: Magri, Meryam, et al.
Publicado: (2023)

Epidemiological risk factors for adult dengue in Singapore: an 8-year nested test negative case control study
por: Yung, Chee Fu, et al.
Publicado: (2016)

Transcriptional Sequencing and Gene Expression Analysis of Various Genes in Fruit Development of Three Different Black Pepper (Piper nigrum L.) Varieties
por: Khew, Choy Yuen, et al.
Publicado: (2020)

N-Acetylglucosamine Inhibits LuxR, LasR and CviR Based Quorum Sensing Regulated Gene Expression Levels
por: Kimyon, Önder, et al.
Publicado: (2016)

Achieving the Optimal Esthetic Outcome of Anterior Restorations: Traditional or Digital Approach?
por: Siaw, Yang-Khim
Publicado: (2018)

LasR-deficient Pseudomonas aeruginosa variants increase airway epithelial mICAM-1 expression and enhance neutrophilic lung inflammation
por: Hennemann, Lisa C., et al.
Publicado: (2021)

Sennoside A inhibits quorum sensing system to attenuate its regulated virulence and pathogenicity via targeting LasR in Pseudomonas aeruginosa
por: Han, Xiaofeng, et al.
Publicado: (2022)

Rett syndrome linked to defects in forming the MeCP2/Rbfox/LASR complex in mouse models
por: Jiang, Yan, et al.
Publicado: (2021)

Study of quorum-sensing LasR and RhlR genes and their dependent virulence factors in Pseudomonas aeruginosa isolates from infected burn wounds
por: Elnegery, Aya Ahmad, et al.
Publicado: (2021)

Identification of anti-pathogenic activity among in silico predicted small-molecule inhibitors of Pseudomonas aeruginosa LasR or nitric oxide reductase (NOR)
por: Gajera, Gemini, et al.
Publicado: (2023)

Composite Fish Collagen-Hyaluronate Based Lyophilized Scaffolds Modified with Sodium Alginate for Potential Treatment of Chronic Wounds
por: Afzali, Meena, et al.
Publicado: (2022)

Short-term Outcomes of Laparoscopy-Assisted vs Open Surgery for Patients With Low Rectal Cancer: The LASRE Randomized Clinical Trial
por: Jiang, Wei-Zhong, et al.
Publicado: (2022)

An Internet Intervention to Improve Asthma Management: Rationale and Protocol of a Randomized Controlled Trial
por: Arguel, Amaël, et al.
Publicado: (2013)

“Why Didn’t it Work?” Lessons From a Randomized Controlled Trial of a Web-based Personally Controlled Health Management System for Adults with Asthma
por: Lau, Annie YS, et al.
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_j5ki97rdijelvhl3itlolbm3du