PAK1 overexpression promotes myxofibrosarcoma angiogenesis through STAT5B-mediated CSF2 transactivation: clinical and therapeutic relevance of amplification and nuclear entry

Myxofibrosarcoma is genetically complex without established nonsurgical therapies. In public datasets, PAK1 was recurrently gained with mRNA upregulation. Using myxofibrosarcoma cells, we explored the oncogenic underpinning of PAK1 with genetic manipulation and a pan-PAK inhibitor (PF3758309). Myxof...

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Detalles Bibliográficos
Autores principales: Li, Chien-Feng, Chan, Ti-Chun, Fang, Fu-Min, Yu, Shih-Chen, Huang, Hsuan-Ying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Ivyspring International Publisher 2023
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10411477/
https://www.ncbi.nlm.nih.gov/pubmed/37564209
http://dx.doi.org/10.7150/ijbs.83467

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10411477/
https://www.ncbi.nlm.nih.gov/pubmed/37564209
http://dx.doi.org/10.7150/ijbs.83467

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