MHC Class II is Induced by IFNγ and Follows Three Distinct Patterns of Expression in Colorectal Cancer Organoids

Tumor-specific MHC class II (tsMHC-II) expression impacts tumor microenvironmental immunity. tsMHC-II positive cancer cells may act as surrogate antigen-presenting cells and targets for CD4(+) T cell–mediated lysis. In colorectal cancer, tsMHC-II negativity is common, in cell lines due to CIITA prom...

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Detalles Bibliográficos
Autores principales: Pickles, Oliver J., Wanigasooriya, Kasun, Ptasinska, Anetta, Patel, Akshay J., Robbins, Helen L., Bryer, Claire, Whalley, Celina M., Tee, Louise, Lal, Neeraj, Pinna, Claudia M.A., Elzefzafy, Nahla, Taniere, Philippe, Beggs, Andrew D., Middleton, Gary M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for Cancer Research 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10411481/
https://www.ncbi.nlm.nih.gov/pubmed/37565053
http://dx.doi.org/10.1158/2767-9764.CRC-23-0091

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10411481/
https://www.ncbi.nlm.nih.gov/pubmed/37565053
http://dx.doi.org/10.1158/2767-9764.CRC-23-0091

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