Mega-scale experimental analysis of protein folding stability in biology and design

Advances in DNA sequencing and machine learning are providing insights into protein sequences and structures on an enormous scale(1). However, the energetics driving folding are invisible in these structures and remain largely unknown(2). The hidden thermodynamics of folding can drive disease(3,4),...

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Detalles Bibliográficos
Autores principales: Tsuboyama, Kotaro, Dauparas, Justas, Chen, Jonathan, Laine, Elodie, Mohseni Behbahani, Yasser, Weinstein, Jonathan J., Mangan, Niall M., Ovchinnikov, Sergey, Rocklin, Gabriel J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10412457/
https://www.ncbi.nlm.nih.gov/pubmed/37468638
http://dx.doi.org/10.1038/s41586-023-06328-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10412457/
https://www.ncbi.nlm.nih.gov/pubmed/37468638
http://dx.doi.org/10.1038/s41586-023-06328-6

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