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Mega-scale experimental analysis of protein folding stability in biology and design
Advances in DNA sequencing and machine learning are providing insights into protein sequences and structures on an enormous scale(1). However, the energetics driving folding are invisible in these structures and remain largely unknown(2). The hidden thermodynamics of folding can drive disease(3,4),...
| Autores principales: | , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10412457/ https://www.ncbi.nlm.nih.gov/pubmed/37468638 http://dx.doi.org/10.1038/s41586-023-06328-6 |