BRCA-deficient metastatic prostate cancer has an adverse prognosis and distinct genomic phenotype

BACKGROUND: Genomic alterations in DNA damage response (DDR) genes are common in metastatic castration-resistant prostate cancer (mCRPC). Understanding how these genomic events impact prognosis and/or treatment response is vital for optimising clinical outcomes. METHODS: Targeted sequencing was perf...

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Detalles Bibliográficos
Autores principales: Fettke, Heidi, Dai, Chao, Kwan, Edmond M., Zheng, Tiantian, Du, Pan, Ng, Nicole, Bukczynska, Patricia, Docanto, Maria, Kostos, Louise, Foroughi, Siavash, Brown, Stephen, Graham, Lisa-Jane K., Mahon, Kate, Horvath, Lisa G., Jia, Shidong, Kohli, Manish, Azad, Arun A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10412463/
https://www.ncbi.nlm.nih.gov/pubmed/37549632
http://dx.doi.org/10.1016/j.ebiom.2023.104738

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10412463/
https://www.ncbi.nlm.nih.gov/pubmed/37549632
http://dx.doi.org/10.1016/j.ebiom.2023.104738

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