Engineered soluble, trimerized 4-1BBL variants as potent immunomodulatory agents

Targeting co-stimulatory receptors promotes the activation and effector functions of anti-tumor lymphocytes. 4-1BB (CD137/TNFSF9), a member of the tumor necrosis factor receptor superfamily (TNFR-SF), is a potent co-stimulatory receptor that plays a prominent role in augmenting effector functions of...

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Detalles Bibliográficos
Autores principales: Battin, Claire, De Sousa Linhares, Annika, Leitner, Judith, Grossmann, Anna, Lupinek, Daniela, Izadi, Shiva, Castilho, Alexandra, Waidhofer-Söllner, Petra, Grabmeier-Pfistershammer, Katharina, Stritzker, Jochen, Steinberger, Peter
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10412504/
https://www.ncbi.nlm.nih.gov/pubmed/37310433
http://dx.doi.org/10.1007/s00262-023-03474-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10412504/
https://www.ncbi.nlm.nih.gov/pubmed/37310433
http://dx.doi.org/10.1007/s00262-023-03474-8

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