Nogo-A antibody delivery through the olfactory mucosa mitigates experimental autoimmune encephalomyelitis in the mouse CNS

Systemic administration of Nogo-A-neutralizing antibody ameliorates experimental autoimmune encephalomyelitis (EAE), an animal model of multiple sclerosis. However, the blood-brain barrier (BBB) is a major obstacle limiting the passage of systemically applied antibody to the CNS. To bypass the BBB,...

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Detalles Bibliográficos
Autores principales: Pernet, Vincent, Joly, Sandrine, Spiegel, Sebastian, Meli, Ivo, Idriss, Sherif, Maigler, Frank, Mdzomba, Julius Baya, Roenneke, Anna K., Franceschini, Alessandra, Silvestri, Ludovico, Pavone, Francesco S., Calamai, Martino, Schindowski, Katharina, Chan, Andrew
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10412545/
https://www.ncbi.nlm.nih.gov/pubmed/37558696
http://dx.doi.org/10.1038/s41420-023-01588-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10412545/
https://www.ncbi.nlm.nih.gov/pubmed/37558696
http://dx.doi.org/10.1038/s41420-023-01588-7

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