Cargando…

Characterizing the role of Phlda3 in the development of acute toxicity and malignant transformation of hematopoietic cells induced by total-body irradiation in mice

The tumor suppressor p53 is a transcriptional factor that plays a crucial role in controlling acute toxicity and long-term malignant transformation of hematopoietic cells induced by genotoxic stress such as ionizing radiation. Among all transcriptional targets of p53, one gene that is robustly induc...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hasapis, Stephanie, Caraballo, Isibel, Sears, Timothy J., Brock, Kennedy D., Cart, John B., Moding, Everett J., Lee, Chang-Lung
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2023
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10412554/ https://www.ncbi.nlm.nih.gov/pubmed/37558703 http://dx.doi.org/10.1038/s41598-023-39678-2

Ejemplares similares

PHLDA1, another PHLDA family protein that inhibits Akt
por: Chen, Yu, et al.
Publicado: (2018)

Total marrow irradiation in hematopoietic stem cell transplantation for hematologic malignancies
por: Kerbauy, Mariana Nassif, et al.
Publicado: (2023)

Delayed Captopril Administration Mitigates Hematopoietic Injury in a Murine Model of Total Body Irradiation
por: McCart, Elizabeth A., et al.
Publicado: (2019)

Phlda3 regulates beta cell survival during stress
por: Bensellam, Mohammed, et al.
Publicado: (2019)

The expression patterns and prognostic significance of pleckstrin homology-like domain family A (PHLDA) in lung cancer and malignant mesothelioma
por: Baldavira, Camila M., et al.
Publicado: (2021)

Characterisation of marsupial PHLDA2 reveals eutherian specific acquisition of imprinting
por: Suzuki, Shunsuke, et al.
Publicado: (2011)

Deletion of the Imprinted Phlda2 Gene Increases Placental Passive Permeability in the Mouse
por: Angiolini, Emily, et al.
Publicado: (2021)

PHLDA1 Mediates Drug Resistance in Receptor Tyrosine Kinase-Driven Cancer
por: Fearon, Abbie E., et al.
Publicado: (2018)

Isolating the role of elevated Phlda2 in asymmetric late fetal growth restriction in mice
por: Tunster, Simon J., et al.
Publicado: (2014)

Liquid Biopsies for Molecular Biology-Based Radiotherapy
por: Blomain, Erik S., et al.
Publicado: (2021)

Effect of dose rate on pulmonary toxicity in patients with hematolymphoid malignancies undergoing total body irradiation
por: Kim, Dong-Yun, et al.
Publicado: (2018)

A vicious partnership between AKT and PHLDA3 to facilitate neuroendocrine tumors
por: Takikawa, Masahiro, et al.
Publicado: (2017)

p53-PHLDA3-Akt Network: The Key Regulators of Neuroendocrine Tumorigenesis
por: Chen, Yu, et al.
Publicado: (2020)

PHLDA1 Does Not Contribute Directly to Heat Shock-Induced Apoptosis of Spermatocytes
por: Janus, Patryk, et al.
Publicado: (2019)

PHLDA1 expression in ulcerative colitis: A potential role in the management of dysplasia
por: Orita, Fukuichiro, et al.
Publicado: (2021)

Prognostic Value, Immune Signature, and Molecular Mechanisms of the PHLDA Family in Pancreatic Adenocarcinoma
por: Duan, Yunjie, et al.
Publicado: (2022)

FGF10 mitigates doxorubicin-induced myocardial toxicity in mice via activation of FGFR2b/PHLDA1/AKT axis
por: Zhou, De-pu, et al.
Publicado: (2023)

Total marrow irradiation for hematopoietic malignancies using volumetric modulated arc therapy: A review of treatment planning studies()()
por: Mancosu, Pietro, et al.
Publicado: (2019)

Epigenetic Modification of Cytosines in Hematopoietic Differentiation and Malignant Transformation
por: An, Jungeun, et al.
Publicado: (2023)

Transcriptome Profiling Reveals PHLDA1 as a Novel Molecular Marker for Ischemic Cardiomyopathy
por: Wang, Jinhui, et al.
Publicado: (2018)

Expression Analysis of GRHL3 and PHLDA3 in Head and Neck Squamous Cell Carcinoma
por: Saffarzadeh, Negin, et al.
Publicado: (2020)

PHLDA1 Suppresses TLR4-Triggered Proinflammatory Cytokine Production by Interaction With Tollip
por: Peng, Hui, et al.
Publicado: (2022)

Sitagliptin Mitigates Total Body Irradiation-Induced Hematopoietic Injury in Mice
por: Wang, Meifang, et al.
Publicado: (2020)

Placental PHLDA2 expression is increased in cases of fetal growth restriction following reduced fetal movements
por: Janssen, Anna Bugge, et al.
Publicado: (2016)

Total body irradiation as part of conditioning regimens in childhood leukemia—long-term outcome, toxicity, and secondary malignancies
por: Gruen, Arne, et al.
Publicado: (2021)

Lentivirus-mediated PHLDA2 overexpression inhibits trophoblast proliferation, migration and invasion, and induces apoptosis
por: JIN, FENG, et al.
Publicado: (2016)

PHLDA3 impedes somatic cell reprogramming by activating Akt-GSK3β pathway
por: Qiao, Mengran, et al.
Publicado: (2017)

Corrigendum: PHLDA1 Suppresses TLR4-Triggered Proinflammatory Cytokine Production by Interaction With Tollip
por: Peng, Hui, et al.
Publicado: (2022)

Late effects of total body irradiation on hematopoietic recovery and immune function in rhesus macaques
por: Hale, Laura P., et al.
Publicado: (2019)

The impacts of total body irradiation on umbilical cord blood hematopoietic stem cell transplantation
por: Wang, Hao, et al.
Publicado: (2023)

Enhanced Effects of Chronic Restraint-Induced Psychological Stress on Total Body Fe-Irradiation-Induced Hematopoietic Toxicity in Trp53-Heterozygous Mice
por: Wang, Bing, et al.
Publicado: (2022)

Reduced-toxicity myeloablative conditioning consisting of 8-Gy total body irradiation, cyclophosphamide and fludarabine for pediatric hematological malignancies
por: Hirabayashi, Koichi, et al.
Publicado: (2014)

The imprinted Phlda2 gene modulates a major endocrine compartment of the placenta to regulate placental demands for maternal resources
por: Tunster, S.J., et al.
Publicado: (2016)

PHLDA1 modulates microglial response and NLRP3 inflammasome signaling following experimental subarachnoid hemorrhage
por: Lai, Jinqing, et al.
Publicado: (2023)

Relationship between placental expression of the imprinted PHLDA2 gene, intrauterine skeletal growth and childhood bone mass()
por: Lewis, R.M., et al.
Publicado: (2012)

Late Toxicity of a Novel Allogeneic Stem Cell Transplant Using Single Fraction Total Body Irradiation for Hematologic Malignancies in Children
por: Madden, Lisa M., et al.
Publicado: (2015)

Impact of total marrow/lymphoid irradiation dose to the intestine on graft-versus-host disease in allogeneic hematopoietic stem cell transplantation for hematologic malignancies
por: Saldi, Simonetta, et al.
Publicado: (2022)

The Yiqi and Yangyin Formula ameliorates injury to the hematopoietic system induced by total body irradiation
por: Zhang, Junling, et al.
Publicado: (2017)

Current Use of Total Body Irradiation in Haploidentical Allogeneic Hematopoietic Stem Cell Transplantation
por: Jung, Jongheon, et al.
Publicado: (2021)

Total Body Irradiation for Hematopoietic Stem Cell Transplantation: What Can We Agree on?
por: Sabloff, Mitchell, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_nrif0ha6sbdjn241h65ji29475