Structure and regulation of full-length human leucine-rich repeat kinase 1

The human leucine-rich repeat kinases (LRRKs), LRRK1 and LRRK2 are large and unusually complex multi-domain kinases, which regulate fundamental cellular processes and have been implicated in human disease. Structures of LRRK2 have recently been determined, but the structure and molecular mechanisms...

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Detalles Bibliográficos
Autores principales: Metcalfe, Riley D., Martinez Fiesco, Juliana A., Bonet-Ponce, Luis, Kluss, Jillian H., Cookson, Mark R., Zhang, Ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10412621/
https://www.ncbi.nlm.nih.gov/pubmed/37558661
http://dx.doi.org/10.1038/s41467-023-40532-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10412621/
https://www.ncbi.nlm.nih.gov/pubmed/37558661
http://dx.doi.org/10.1038/s41467-023-40532-2

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