Nitric oxide suppression by secreted frizzled-related protein 2 drives retinoblastoma

Retinoblastoma is a cancer of the infant retina primarily driven by loss of the Rb tumor suppressor gene, which is undruggable. Here, we report an autocrine signaling, mediated by secreted frizzled-related protein 2 (SFRP2), which suppresses nitric oxide and enables retinoblastoma growth. We show th...

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Detalles Bibliográficos
Autores principales: Jayabal, Panneerselvam, Zhou, Fuchun, Ma, Xiuye, Bondra, Kathryn M., Blackman, Barron, Weintraub, Susan T., Chen, Yidong, Chévez-Barrios, Patricia, Houghton, Peter J., Gallie, Brenda, Shiio, Yuzuru
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10412738/
https://www.ncbi.nlm.nih.gov/pubmed/36773293
http://dx.doi.org/10.1016/j.celrep.2023.112103

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10412738/
https://www.ncbi.nlm.nih.gov/pubmed/36773293
http://dx.doi.org/10.1016/j.celrep.2023.112103

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