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Tryptophan metabolism promotes immune evasion in human pancreatic β cells
BACKGROUND: To resist the autoimmune attack characteristic of type 1 diabetes, insulin producing pancreatic β cells need to evade T-cell recognition. Such escape mechanisms may be conferred by low HLA class I (HLA-I) expression and upregulation of immune inhibitory molecules such as Programmed cell...
| Autores principales: | , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2023
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10412781/ https://www.ncbi.nlm.nih.gov/pubmed/37536063 http://dx.doi.org/10.1016/j.ebiom.2023.104740 |