Clinicopathological Parameters of Haemophilia Patients at a Tertiary Care Centre in Northern India

Introduction: Haemophilia affects a large number of people all over the world, yet very little is known about the clinical manifestations and diagnostic protocols of the condition in areas with limited access to resources in developing countries. Understanding the clinical spectrum and diagnostic ap...

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Autores principales: Singh, Anurag, Rawat, Shalini, Kushwaha, Rashmi, Jain, Mili, Verma, Shailendra P, Singh, U.S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10412897/
https://www.ncbi.nlm.nih.gov/pubmed/37575728
http://dx.doi.org/10.7759/cureus.41670
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author Singh, Anurag
Rawat, Shalini
Kushwaha, Rashmi
Jain, Mili
Verma, Shailendra P
Singh, U.S.
author_facet Singh, Anurag
Rawat, Shalini
Kushwaha, Rashmi
Jain, Mili
Verma, Shailendra P
Singh, U.S.
author_sort Singh, Anurag
collection PubMed
description Introduction: Haemophilia affects a large number of people all over the world, yet very little is known about the clinical manifestations and diagnostic protocols of the condition in areas with limited access to resources in developing countries. Understanding the clinical spectrum and diagnostic approach will help with the design of measures to address the situation in these places. The primary objective of this study was to examine the clinicopathological parameters of haemophiliac patients. Materials and methods: From the departmental archive, a thorough history of each patient was retrieved, including values of bleeding time, prothrombin time, activated partial prothrombin time, and percentage of specific factor activity. Results: Out of a total of 385 cases over the period of six years, 86.75% were classified as haemophilia A and 13.25% of cases were diagnosed as haemophilia B. In terms of the severity of the disease, 44.93% were classified as severe, 42.08% as moderate, and 12.99% as mild. Joint bleeding was the first and most typical clinical manifestation of the disease, accounting for 34.80% of cases, followed by ecchymosis (23.12%), post-traumatic bleeding (12.73%), epistaxis (12.20%), and gum bleeding (8.05%). 1.56% of patients had a positive screening test for the hepatitis C virus, followed by 1.30% for HIV and 0.78% for hepatitis B surface antigen. Conclusion: In the presence of joint bleeding, ecchymosis, and post-traumatic bleeding in an otherwise healthy individual, a clinician should be alerted to the possibility that the patient has haemophilia and should request a work-up for the bleeding disorder.
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spelling pubmed-104128972023-08-11 Clinicopathological Parameters of Haemophilia Patients at a Tertiary Care Centre in Northern India Singh, Anurag Rawat, Shalini Kushwaha, Rashmi Jain, Mili Verma, Shailendra P Singh, U.S. Cureus Pathology Introduction: Haemophilia affects a large number of people all over the world, yet very little is known about the clinical manifestations and diagnostic protocols of the condition in areas with limited access to resources in developing countries. Understanding the clinical spectrum and diagnostic approach will help with the design of measures to address the situation in these places. The primary objective of this study was to examine the clinicopathological parameters of haemophiliac patients. Materials and methods: From the departmental archive, a thorough history of each patient was retrieved, including values of bleeding time, prothrombin time, activated partial prothrombin time, and percentage of specific factor activity. Results: Out of a total of 385 cases over the period of six years, 86.75% were classified as haemophilia A and 13.25% of cases were diagnosed as haemophilia B. In terms of the severity of the disease, 44.93% were classified as severe, 42.08% as moderate, and 12.99% as mild. Joint bleeding was the first and most typical clinical manifestation of the disease, accounting for 34.80% of cases, followed by ecchymosis (23.12%), post-traumatic bleeding (12.73%), epistaxis (12.20%), and gum bleeding (8.05%). 1.56% of patients had a positive screening test for the hepatitis C virus, followed by 1.30% for HIV and 0.78% for hepatitis B surface antigen. Conclusion: In the presence of joint bleeding, ecchymosis, and post-traumatic bleeding in an otherwise healthy individual, a clinician should be alerted to the possibility that the patient has haemophilia and should request a work-up for the bleeding disorder. Cureus 2023-07-10 /pmc/articles/PMC10412897/ /pubmed/37575728 http://dx.doi.org/10.7759/cureus.41670 Text en Copyright © 2023, Singh et al. https://creativecommons.org/licenses/by/3.0/This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Pathology
Singh, Anurag
Rawat, Shalini
Kushwaha, Rashmi
Jain, Mili
Verma, Shailendra P
Singh, U.S.
Clinicopathological Parameters of Haemophilia Patients at a Tertiary Care Centre in Northern India
title Clinicopathological Parameters of Haemophilia Patients at a Tertiary Care Centre in Northern India
title_full Clinicopathological Parameters of Haemophilia Patients at a Tertiary Care Centre in Northern India
title_fullStr Clinicopathological Parameters of Haemophilia Patients at a Tertiary Care Centre in Northern India
title_full_unstemmed Clinicopathological Parameters of Haemophilia Patients at a Tertiary Care Centre in Northern India
title_short Clinicopathological Parameters of Haemophilia Patients at a Tertiary Care Centre in Northern India
title_sort clinicopathological parameters of haemophilia patients at a tertiary care centre in northern india
topic Pathology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10412897/
https://www.ncbi.nlm.nih.gov/pubmed/37575728
http://dx.doi.org/10.7759/cureus.41670
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