Palmitoylation-dependent control of JAK1 kinase signaling governs responses to neuropoietic cytokines and survival in DRG neurons

Janus Kinase-1 (JAK1) plays key roles during neurodevelopment and following neuronal injury, while activatory JAK1 mutations are linked to leukemia. In mice, Jak1 genetic deletion results in perinatal lethality, suggesting non-redundant roles and/or regulation of JAK1 for which other JAKs cannot com...

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Detalles Bibliográficos
Autores principales: Hernandez, Luiselys M., Montersino, Audrey, Niu, Jingwen, Guo, Shuchi, Faezov, Bulat, Sanders, Shaun S., Dunbrack, Roland L., Thomas, Gareth M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10413081/
https://www.ncbi.nlm.nih.gov/pubmed/37356718
http://dx.doi.org/10.1016/j.jbc.2023.104965

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10413081/
https://www.ncbi.nlm.nih.gov/pubmed/37356718
http://dx.doi.org/10.1016/j.jbc.2023.104965

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