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Palmitoylation-dependent control of JAK1 kinase signaling governs responses to neuropoietic cytokines and survival in DRG neurons

Janus Kinase-1 (JAK1) plays key roles during neurodevelopment and following neuronal injury, while activatory JAK1 mutations are linked to leukemia. In mice, Jak1 genetic deletion results in perinatal lethality, suggesting non-redundant roles and/or regulation of JAK1 for which other JAKs cannot com...

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Detalles Bibliográficos
Autores principales:	Hernandez, Luiselys M., Montersino, Audrey, Niu, Jingwen, Guo, Shuchi, Faezov, Bulat, Sanders, Shaun S., Dunbrack, Roland L., Thomas, Gareth M.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10413081/ https://www.ncbi.nlm.nih.gov/pubmed/37356718 http://dx.doi.org/10.1016/j.jbc.2023.104965

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