The microbial genotoxin colibactin exacerbates mismatch repair mutations in colorectal tumors

Certain Enterobacteriaceae strains contain a 54-kb biosynthetic gene cluster referred to as “pks” encoding the biosynthesis of a secondary metabolite, colibactin. Colibactin-producing E. coli promote colorectal cancer (CRC) in preclinical models, and in vitro induce a specific mutational signature t...

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Detalles Bibliográficos
Autores principales: Dougherty, Michael W., Valdés-Mas, Rafael, Wernke, Kevin M., Gharaibeh, Raad Z., Yang, Ye, Brant, Jason O., Riva, Alberto, Muehlbauer, Marcus, Elinav, Eran, Puschhof, Jens, Herzon, Seth B., Jobin, Christian
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Neoplasia Press 2023
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10413156/
https://www.ncbi.nlm.nih.gov/pubmed/37499275
http://dx.doi.org/10.1016/j.neo.2023.100918

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10413156/
https://www.ncbi.nlm.nih.gov/pubmed/37499275
http://dx.doi.org/10.1016/j.neo.2023.100918

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