Tail-approach based design, synthesis, and cytotoxic evaluation of novel disubstituted and trisubstituted 1,3-thiazole benzenesulfonamide derivatives with suggested carbonic anhydrase IX inhibition mechanism

A novel series of 2,4,5- and 2,3,4-trisubstituted thiazole hybrids with 1,3,4-thiadiazolylbenzenesulfonamide was designed following the tail approach as possible hCAIX inhibitors. The key intermediate 1 was condensed with thiosemicarbazide 2a to give 1,3,4-thiadiazolylthiosemicarbazone 3, which upon...

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Detalles Bibliográficos
Autores principales: Bondock, Samir, Albarqi, Tallah, Abboud, Mohamed, Nasr, Tamer, Mohamed, Nada M., Abdou, Moaz M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: The Royal Society of Chemistry 2023
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10413337/
https://www.ncbi.nlm.nih.gov/pubmed/37577088
http://dx.doi.org/10.1039/d3ra02528d

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10413337/
https://www.ncbi.nlm.nih.gov/pubmed/37577088
http://dx.doi.org/10.1039/d3ra02528d

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