Computational redesign of cytochrome P450 CYP102A1 for highly stereoselective omeprazole hydroxylation by UniDesign

Cytochrome P450 CYP102A1 is a prototypic biocatalyst that has great potential in chemical synthesis, drug discovery, and biotechnology. CYP102A1 variants engineered by directed evolution and/or rational design are capable of catalyzing the oxidation of a wide range of organic compounds. However, it...

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Detalles Bibliográficos
Autores principales: Huang, Xiaoqiang, Sun, Yudong, Osawa, Yoichi, Chen, Y. Eugene, Zhang, Haoming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Biochemistry and Molecular Biology 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10413352/
https://www.ncbi.nlm.nih.gov/pubmed/37451479
http://dx.doi.org/10.1016/j.jbc.2023.105050

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10413352/
https://www.ncbi.nlm.nih.gov/pubmed/37451479
http://dx.doi.org/10.1016/j.jbc.2023.105050

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