Cargando…

Computational redesign of cytochrome P450 CYP102A1 for highly stereoselective omeprazole hydroxylation by UniDesign

Cytochrome P450 CYP102A1 is a prototypic biocatalyst that has great potential in chemical synthesis, drug discovery, and biotechnology. CYP102A1 variants engineered by directed evolution and/or rational design are capable of catalyzing the oxidation of a wide range of organic compounds. However, it...

Descripción completa

Detalles Bibliográficos
Autores principales:	Huang, Xiaoqiang, Sun, Yudong, Osawa, Yoichi, Chen, Y. Eugene, Zhang, Haoming
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Society for Biochemistry and Molecular Biology 2023
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10413352/ https://www.ncbi.nlm.nih.gov/pubmed/37451479 http://dx.doi.org/10.1016/j.jbc.2023.105050

Ejemplares similares

The Versatile Biocatalyst of Cytochrome P450 CYP102A1: Structure, Function, and Engineering
por: Sun, Yudong, et al.
Publicado: (2023)

Exploring the Potential of Cytochrome P450 CYP109B1 Catalyzed Regio—and Stereoselective Steroid Hydroxylation
por: Zhang, Xiaodong, et al.
Publicado: (2021)

Amphipol-facilitated elucidation of the functional tetrameric complex of full-length cytochrome P450 CYP2B4 and NADPH-cytochrome P450 oxidoreductase
por: Cheng, Shen, et al.
Publicado: (2021)

Regio‐ and Stereoselective Steroid Hydroxylation at C7 by Cytochrome P450 Monooxygenase Mutants
por: Li, Aitao, et al.
Publicado: (2020)

Redesigning Aldolase Stereoselectivity by Homologous Grafting
por: Bisterfeld, Carolin, et al.
Publicado: (2016)

The cytochrome P450 (CYP) superfamily in cnidarians
por: Pankov, Kirill V., et al.
Publicado: (2021)

Role of residue 87 in substrate selectivity and regioselectivity of drug-metabolizing cytochrome P450 CYP102A1 M11
por: Vottero, Eduardo, et al.
Publicado: (2011)

Influence of Amlodipine Enantiomers on Human Microsomal Cytochromes P450: Stereoselective Time-Dependent Inhibition of CYP3A Enzyme Activity
por: Krasulova, Kristyna, et al.
Publicado: (2017)

Characterization of kinetics of human cytochrome P450s involved in bioactivation of flucloxacillin: inhibition of CYP3A‐catalysed hydroxylation by sulfaphenazole
por: Dekker, Stefan J, et al.
Publicado: (2018)

Hydroxylation index of omeprazole in relation to CYP2C19 polymorphism and sex in a healthy Iranian population
por: Payan, Maryam, et al.
Publicado: (2014)

LmCYP4G102: An oenocyte-specific cytochrome P450 gene required for cuticular waterproofing in the migratory locust, Locusta migratoria
por: Yu, Zhitao, et al.
Publicado: (2016)

Succinic acid inhibits the activity of cytochrome P450 (CYP450) enzymes
por: Wang, Hao, et al.
Publicado: (2020)

Hydroxylation of Antitubercular Drug Candidate, SQ109, by Mycobacterial Cytochrome P450
por: Bukhdruker, Sergey, et al.
Publicado: (2020)

Hydroxyl-Directed Stereoselective Diboration of Alkenes
por: Blaisdell, Thomas P., et al.
Publicado: (2014)

Mechanistic Insights into the Regio‐ and Stereoselectivities of Testosterone and Dihydrotestosterone Hydroxylation Catalyzed by CYP3A4 and CYP19A1
por: Li, Junhao, et al.
Publicado: (2020)

The cytochrome P450 (CYP) gene superfamily in Daphnia pulex
por: Baldwin, William S, et al.
Publicado: (2009)

Exploring the Factors which Result in Cytochrome P450 Catalyzed Desaturation Versus Hydroxylation
por: Coleman, Tom, et al.
Publicado: (2022)

Detection of microwave radiation of cytochrome CYP102 A1 solution during the enzyme reaction
por: Ivanov, Yu.D., et al.
Publicado: (2015)

MutaCYP: Classification of missense mutations in human cytochromes P450
por: Fechter, Kenneth, et al.
Publicado: (2014)

Polymorphic Cytochrome P450 Enzymes (CYPs) and Their Role in Personalized Therapy
por: Preissner, Sarah C., et al.
Publicado: (2013)

Modeling of interactions between xenobiotics and cytochrome P450 (CYP) enzymes
por: Raunio, Hannu, et al.
Publicado: (2015)

Phylogenetic analysis of the cytochrome P450 (CYP450) nucleotide sequences of the horse and predicted CYP450s of the white rhinoceros (Ceratotherium simum) and other mammalian species
por: Leiberich, Marion, et al.
Publicado: (2018)

Kinetic Analysis of Lauric Acid Hydroxylation by Human Cytochrome P450 4A11
por: Kim, Donghak, et al.
Publicado: (2014)

Role of cytochrome P450 2D6 genetic polymorphism in carvedilol hydroxylation in vitro
por: Wang, Zhe, et al.
Publicado: (2016)

Cloning and Expression of a Perilla frutescens Cytochrome P450 Enzyme Catalyzing the Hydroxylation of Phenylpropenes
por: Baba, Mariko, et al.
Publicado: (2020)

Enabling Aromatic Hydroxylation in a Cytochrome P450 Monooxygenase Enzyme through Protein Engineering
por: Coleman, Tom, et al.
Publicado: (2022)

Theoretical Study of Hydroxylation of α- and β-Pinene by a Cytochrome P450 Monooxygenase Model
por: Shaya, Janah, et al.
Publicado: (2023)

Identification of 74 cytochrome P450 genes and co-localized cytochrome P450 genes of the CYP2K, CYP5A, and CYP46A subfamilies in the mangrove killifish Kryptolebias marmoratus
por: Lee, Bo-Young, et al.
Publicado: (2018)

Antihypertensive Effect Of Amlodipine In Co-Administration With Omeprazole In Patients With Hypertension And Acid-Related Disorders: Cytochrome P450-Associated Aspects
por: Dorofeeva, Margarita N, et al.
Publicado: (2019)

Cytochrome P450 CYP3A in human renal cell cancer
por: Murray, G I, et al.
Publicado: (1999)

Analysis of polymorphisms of canine Cytochrome P 450‐CYP2D15
por: van Hagen, Marjan A. E., et al.
Publicado: (2020)

Tyrosine Hydroxylation in Betalain Pigment Biosynthesis Is Performed by Cytochrome P450 Enzymes in Beets (Beta vulgaris)
por: Sunnadeniya, Rasika, et al.
Publicado: (2016)

Computational Insight Into Vitamin K(1) ω-Hydroxylation by Cytochrome P450 4F2
por: Li, Junhao, et al.
Publicado: (2018)

Regioselective Hydroxylation of Phloretin, a Bioactive Compound from Apples, by Human Cytochrome P450 Enzymes
por: Nguyen, Ngoc Anh, et al.
Publicado: (2020)

Conversion of viridicatic acid to crustosic acid by cytochrome P450 enzyme-catalysed hydroxylation and spontaneous cyclisation
por: Zhou, Jenny, et al.
Publicado: (2021)

Cholesterol Hydroxylating Cytochrome P450 46A1: From Mechanisms of Action to Clinical Applications
por: Pikuleva, Irina A., et al.
Publicado: (2021)

Epoxidation Activities of Human Cytochromes P450c17 and P450c21
por: Yoshimoto, Francis K., et al.
Publicado: (2014)

Cytochrome P450 CYP1B1 activity in renal cell carcinoma
por: McFadyen, M C E, et al.
Publicado: (2004)

Nonalcoholic Fatty Liver Disease (NAFLD) and Hepatic Cytochrome P450 (CYP) Enzymes
por: Jamwal, Rohitash, et al.
Publicado: (2020)

The cytochrome P450 Cyp6t3 is not required for ecdysone biosynthesis in Drosophila melanogaster
por: Shimell, MaryJane, et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_630gs7hftk8aqroufvvngv8fk3