Stereoselective Solvolysis in the Synthesis of Dorzolamide Intermediates

[Image: see text] The key intermediate in the synthesis of dorzolamide, (4S,6S)-methyl-5,6-dihydro-4H-thieno[2,3-b]thiopyran-4-ol-7,7-dioxide, can be obtained in the diastereoisomerically pure form in two straightforward steps starting from diastereoisomeric mixtures of cis/trans-(6S)-6-methyl-5,6-d...

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Detalles Bibliográficos
Autores principales: Martinelli, Andrea, Volpicelli, Raffaella, Verzini, Massimo, Cotarca, Livius, Maini, Lucia, Pengo, Paolo, Pasquato, Lucia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10413462/
https://www.ncbi.nlm.nih.gov/pubmed/37576669
http://dx.doi.org/10.1021/acsomega.3c03959

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10413462/
https://www.ncbi.nlm.nih.gov/pubmed/37576669
http://dx.doi.org/10.1021/acsomega.3c03959

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