Target delivery of a PD-1-TREM2 scFv by CAR-T cells enhances anti-tumor efficacy in colorectal cancer

BACKGROUND: Chimeric antigen receptor (CAR) -T cell therapy is an efficient therapeutic strategy for specific hematologic malignancies. However, positive outcomes of this novel therapy in treating solid tumors are curtailed by the immunosuppressive tumor microenvironment (TME), wherein signaling of...

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Detalles Bibliográficos
Autores principales: Chen, Jian, Zhu, Tianchuan, Jiang, Guanmin, Zeng, Qi, Li, Zhijian, Huang, Xi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10413520/
https://www.ncbi.nlm.nih.gov/pubmed/37563723
http://dx.doi.org/10.1186/s12943-023-01830-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10413520/
https://www.ncbi.nlm.nih.gov/pubmed/37563723
http://dx.doi.org/10.1186/s12943-023-01830-x

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