Creation of distinctive Bax-lipid complexes at mitochondrial membrane surfaces drives pore formation to initiate apoptosis

Apotosis is an essential process tightly regulated by the Bcl-2 protein family where proapoptotic Bax triggers cell death by perforating the mitochondrial outer membrane. Although intensively studied, the molecular mechanism by which these proteins create apoptotic pores remains elusive. Here, we sh...

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Detalles Bibliográficos
Autores principales: Clifton, Luke A., Wacklin-Knecht, Hanna P., Ådén, Jörgen, Mushtaq, Ameeq Ul, Sparrman, Tobias, Gröbner, Gerhard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2023
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10413641/
https://www.ncbi.nlm.nih.gov/pubmed/37267355
http://dx.doi.org/10.1126/sciadv.adg7940

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10413641/
https://www.ncbi.nlm.nih.gov/pubmed/37267355
http://dx.doi.org/10.1126/sciadv.adg7940

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