Structural basis of purine nucleotide inhibition of human uncoupling protein 1

Mitochondrial uncoupling protein 1 (UCP1) gives brown adipose tissue of mammals its specialized ability to burn calories as heat for thermoregulation. When activated by fatty acids, UCP1 catalyzes the leak of protons across the mitochondrial inner membrane, short-circuiting the mitochondrion to gene...

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Detalles Bibliográficos
Autores principales: Jones, Scott A., Gogoi, Prerana, Ruprecht, Jonathan J., King, Martin S., Lee, Yang, Zögg, Thomas, Pardon, Els, Chand, Deepak, Steimle, Stefan, Copeman, Danielle M., Cotrim, Camila A., Steyaert, Jan, Crichton, Paul G., Moiseenkova-Bell, Vera, Kunji, Edmund R. S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2023
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10413660/
https://www.ncbi.nlm.nih.gov/pubmed/37256948
http://dx.doi.org/10.1126/sciadv.adh4251

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10413660/
https://www.ncbi.nlm.nih.gov/pubmed/37256948
http://dx.doi.org/10.1126/sciadv.adh4251

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