Cryo-EM visualization of DNA-PKcs structural intermediates in NHEJ

DNA double-strand breaks (DSBs), one of the most cytotoxic forms of DNA damage, can be repaired by the tightly regulated nonhomologous end joining (NHEJ) machinery (Stinson and Loparo and Zhao et al.). Core NHEJ factors form an initial long-range (LR) synaptic complex that transitions into a DNA-PKc...

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Detalles Bibliográficos
Autores principales: Chen, Siyu, Vogt, Alex, Lee, Linda, Naila, Tasmin, McKeown, Ryan, Tomkinson, Alan E, Lees-Miller, Susan P, He, Yuan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2023
Materias:
Biomedicine and Life Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10413680/
https://www.ncbi.nlm.nih.gov/pubmed/37256947
http://dx.doi.org/10.1126/sciadv.adg2838

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10413680/
https://www.ncbi.nlm.nih.gov/pubmed/37256947
http://dx.doi.org/10.1126/sciadv.adg2838

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