Investigating the Unbinding of Muscarinic Antagonists from the Muscarinic 3 Receptor

[Image: see text] Patient symptom relief is often heavily influenced by the residence time of the inhibitor–target complex. For the human muscarinic receptor 3 (hMR3), tiotropium is a long-acting bronchodilator used in conditions such as asthma or chronic obstructive pulmonary disease (COPD). The me...

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Detalles Bibliográficos
Autores principales: Buigues, Pedro J., Gehrke, Sascha, Badaoui, Magd, Dudas, Balint, Mandana, Gaurav, Qi, Tianyun, Bottegoni, Giovanni, Rosta, Edina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2023
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10413856/
https://www.ncbi.nlm.nih.gov/pubmed/37458730
http://dx.doi.org/10.1021/acs.jctc.3c00023

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10413856/
https://www.ncbi.nlm.nih.gov/pubmed/37458730
http://dx.doi.org/10.1021/acs.jctc.3c00023

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