Interplay of heavy chain introns influences efficient transcript splicing and affects product quality of recombinant biotherapeutic antibodies from CHO cells

Introns are included in genes encoding therapeutic proteins for their well-documented function of boosting expression. However, mis-splicing of introns in recombinant immunoglobulin (IgG) heavy chain (HC) transcripts can produce amino acid sequence product variants. These variants can affect product...

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Detalles Bibliográficos
Autores principales: Kelsall, Emma, Harris, Claire, Sen, Titash, Hatton, Diane, Dunn, Sarah, Gibson, Suzanne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2023
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10413919/
https://www.ncbi.nlm.nih.gov/pubmed/37555672
http://dx.doi.org/10.1080/19420862.2023.2242548

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10413919/
https://www.ncbi.nlm.nih.gov/pubmed/37555672
http://dx.doi.org/10.1080/19420862.2023.2242548

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