Structures of SARS-CoV-2 N7-methyltransferase with DOT1L and PRMT7 inhibitors provide a platform for new antivirals

The RNA N7-methyltransferase (MTase) activity of SARS-CoV-2’s nsp14 protein is essential for viral replication and is a target for the development of new antivirals. Nsp14 uses S-adenosyl methionine (SAM) as the methyl donor to cap the 5’ end of the SARS-CoV-2 mRNA and generates S-adenosyl homocyste...

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Detalles Bibliográficos
Autores principales: Kottur, Jithesh, White, Kris M., Rodriguez, M. Luis, Rechkoblit, Olga, Quintana-Feliciano, Richard, Nayar, Ahana, García-Sastre, Adolfo, Aggarwal, Aneel K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2023
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10414583/
https://www.ncbi.nlm.nih.gov/pubmed/37523415
http://dx.doi.org/10.1371/journal.ppat.1011546

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10414583/
https://www.ncbi.nlm.nih.gov/pubmed/37523415
http://dx.doi.org/10.1371/journal.ppat.1011546

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