Metallohelices stabilize DNA three-way junctions and induce DNA damage in cancer cells

DNA three-way junctions (3WJ) represent one of the simplest supramolecular DNA structures arising as intermediates in homologous recombination in the absence of replication. They are also formed transiently during DNA replication. Here we examine the ability of Fe(II)-based metallohelices to act as...

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Detalles Bibliográficos
Autores principales: Malina, Jaroslav, Kostrhunova, Hana, Scott, Peter, Brabec, Viktor
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Chemical Biology and Nucleic Acid Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10415117/
https://www.ncbi.nlm.nih.gov/pubmed/37351627
http://dx.doi.org/10.1093/nar/gkad536

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10415117/
https://www.ncbi.nlm.nih.gov/pubmed/37351627
http://dx.doi.org/10.1093/nar/gkad536

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