ATM–ESCO2–SMC3 axis promotes 53BP1 recruitment in response to DNA damage and safeguards genome integrity by stabilizing cohesin complex

53BP1 is primarily known as a key regulator in DNA double-strand break (DSB) repair. However, the mechanism of DSB-triggered cohesin modification-modulated chromatin structure on the recruitment of 53BP1 remains largely elusive. Here, we identified acetyltransferase ESCO2 as a regulator for DSB-indu...

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Detalles Bibliográficos
Autores principales: Fu, Jianfeng, Zhou, Siru, Xu, Huilin, Liao, Liming, Shen, Hui, Du, Peng, Zheng, Xiaofeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10415120/
https://www.ncbi.nlm.nih.gov/pubmed/37377435
http://dx.doi.org/10.1093/nar/gkad533

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10415120/
https://www.ncbi.nlm.nih.gov/pubmed/37377435
http://dx.doi.org/10.1093/nar/gkad533

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