The role of catalytic and regulatory domains of human PrimPol in DNA binding and synthesis

Human PrimPol possesses DNA primase and DNA polymerase activities and restarts stalled replication forks protecting cells against DNA damage in nuclei and mitochondria. The zinc-binding motif (ZnFn) of the C-terminal domain (CTD) of PrimPol is required for DNA primase activity but the mechanism is n...

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Detalles Bibliográficos
Autores principales: Boldinova, Elizaveta O, Baranovskiy, Andrey G, Gagarinskaya, Diana I, Manukyan, Anna A, Makarova, Alena V, Tahirov, Tahir H
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Nucleic Acid Enzymes
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10415149/
https://www.ncbi.nlm.nih.gov/pubmed/37326028
http://dx.doi.org/10.1093/nar/gkad507

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10415149/
https://www.ncbi.nlm.nih.gov/pubmed/37326028
http://dx.doi.org/10.1093/nar/gkad507

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