Five nucleotides found in RCTG motifs are essential for post-fertilization methylation imprinting of the H19 ICR in YAC transgenic mice

Genomic imprinting at the mouse Igf2/H19 locus is controlled by the H19 ICR, within which paternal allele-specific DNA methylation originating in sperm is maintained throughout development in offspring. We previously found that a 2.9 kb transgenic H19 ICR fragment in mice can be methylated de novo a...

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Detalles Bibliográficos
Autores principales: Matsuzaki, Hitomi, Takahashi, Takuya, Kuramochi, Daichi, Hirakawa, Katsuhiko, Tanimoto, Keiji
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Gene regulation, Chromatin and Epigenetics
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10415150/
https://www.ncbi.nlm.nih.gov/pubmed/37334871
http://dx.doi.org/10.1093/nar/gkad516

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10415150/
https://www.ncbi.nlm.nih.gov/pubmed/37334871
http://dx.doi.org/10.1093/nar/gkad516

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