Enhanced mitochondrial G-quadruplex formation impedes replication fork progression leading to mtDNA loss in human cells

Mitochondrial DNA (mtDNA) replication stalling is considered an initial step in the formation of mtDNA deletions that associate with genetic inherited disorders and aging. However, the molecular details of how stalled replication forks lead to mtDNA deletions accumulation are still unclear. Mitochon...

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Detalles Bibliográficos
Autores principales: Doimo, Mara, Chaudhari, Namrata, Abrahamsson, Sanna, L’Hôte, Valentin, Nguyen, Tran V H, Berner, Andreas, Ndi, Mama, Abrahamsson, Alva, Das, Rabindra Nath, Aasumets, Koit, Goffart, Steffi, Pohjoismäki, Jaakko L O, López, Marcela Dávila, Chorell, Erik, Wanrooij, Sjoerd
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2023
Materias:
Genome Integrity, Repair and Replication
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10415151/
https://www.ncbi.nlm.nih.gov/pubmed/37351621
http://dx.doi.org/10.1093/nar/gkad535

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10415151/
https://www.ncbi.nlm.nih.gov/pubmed/37351621
http://dx.doi.org/10.1093/nar/gkad535

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