MTH1 protects platelet mitochondria from oxidative damage and regulates platelet function and thrombosis

Human MutT Homolog 1 (MTH1) is a nucleotide pool sanitization enzyme that hydrolyzes oxidized nucleotides to prevent their mis-incorporation into DNA under oxidative stress. Expression and functional roles of MTH1 in platelets are not known. Here, we show MTH1 expression in platelets and its deficie...

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Detalles Bibliográficos
Autores principales: Ding, Yangyang, Gui, Xiang, Chu, Xiang, Sun, Yueyue, Zhang, Sixuan, Tong, Huan, Ju, Wen, Li, Yue, Sun, Zengtian, Xu, Mengdi, Li, Zhenyu, Andrews, Robert K., Gardiner, Elizabeth E., Zeng, Lingyu, Xu, Kailin, Qiao, Jianlin
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10415391/
https://www.ncbi.nlm.nih.gov/pubmed/37563135
http://dx.doi.org/10.1038/s41467-023-40600-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10415391/
https://www.ncbi.nlm.nih.gov/pubmed/37563135
http://dx.doi.org/10.1038/s41467-023-40600-7

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