The E3 Ubiquitin Ligase SCF Cyclin F Promotes Sequestosome-1/p62 Insolubility and Foci Formation and is Dysregulated in ALS and FTD Pathogenesis

Amyotrophic lateral sclerosis (ALS)- and frontotemporal dementia (FTD)-linked mutations in CCNF have been shown to cause dysregulation to protein homeostasis. CCNF encodes for cyclin F, which is part of the cyclin F-E3 ligase complex SCF(cyclinF) known to ubiquitylate substrates for proteasomal degr...

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Detalles Bibliográficos
Autores principales: Davidson, Jennilee M., Wu, Sharlynn S. L., Rayner, Stephanie L., Cheng, Flora, Duncan, Kimberley, Russo, Carlo, Newbery, Michelle, Ding, Kunjie, Scherer, Natalie M., Balez, Rachelle, García-Redondo, Alberto, Rábano, Alberto, Rosa-Fernandes, Livia, Ooi, Lezanne, Williams, Kelly L., Morsch, Marco, Blair, Ian P., Di Ieva, Antonio, Yang, Shu, Chung, Roger S., Lee, Albert
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2023
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10415446/
https://www.ncbi.nlm.nih.gov/pubmed/37243816
http://dx.doi.org/10.1007/s12035-023-03355-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10415446/
https://www.ncbi.nlm.nih.gov/pubmed/37243816
http://dx.doi.org/10.1007/s12035-023-03355-2

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