Synthesis and molecular docking of new N4-piperazinyl ciprofloxacin hybrids as antimicrobial DNA gyrase inhibitors

ABSTRACT: A series of N-4 piperazinyl ciprofloxacin derivatives as urea-tethered ciprofloxacin-chalcone hybrids 2a-j and thioacetyl-linked ciprofloxacin-pyrimidine hybrids 5a-i were synthesized. The target compounds were investigated for their antibacterial activity against S. aureus, P. aeruginosa,...

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Detalles Bibliográficos
Autores principales: Mohammed, Hamada H. H., Ali, Doaa Mohamed Elroby, Badr, Mohamed, Habib, Ahmed G. K., Mahmoud, Abobakr Mohamed, Farhan, Sarah M., Gany, Shimaa Salah Hassan Abd El, Mohamad, Soad A., Hayallah, Alaa M., Abbas, Samar H., Abuo-Rahma, Gamal El-Din A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2022
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10415461/
https://www.ncbi.nlm.nih.gov/pubmed/36152132
http://dx.doi.org/10.1007/s11030-022-10528-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10415461/
https://www.ncbi.nlm.nih.gov/pubmed/36152132
http://dx.doi.org/10.1007/s11030-022-10528-z

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