Parallel shift of DNA methylation and gene expression toward the mean in mouse spleen with aging

Age-associated DNA-methylation drift (AMD) manifests itself in two ways in mammals: global decrease (hypomethylation) and local increase of DNA methylation (hypermethylation). To comprehend the principle behind this bidirectional AMD, we studied methylation states of spatially clustered CpG dinucleo...

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Detalles Bibliográficos
Autores principales: Jeong, Sangkyun, Cho, Sunwha, Yang, Seung Kyoung, Oh, Soo A., Kang, Yong-Kook
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals 2023
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10415566/
https://www.ncbi.nlm.nih.gov/pubmed/37494662
http://dx.doi.org/10.18632/aging.204903

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10415566/
https://www.ncbi.nlm.nih.gov/pubmed/37494662
http://dx.doi.org/10.18632/aging.204903

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