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Parallel shift of DNA methylation and gene expression toward the mean in mouse spleen with aging
Age-associated DNA-methylation drift (AMD) manifests itself in two ways in mammals: global decrease (hypomethylation) and local increase of DNA methylation (hypermethylation). To comprehend the principle behind this bidirectional AMD, we studied methylation states of spatially clustered CpG dinucleo...
Autores principales: | Jeong, Sangkyun, Cho, Sunwha, Yang, Seung Kyoung, Oh, Soo A., Kang, Yong-Kook |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10415566/ https://www.ncbi.nlm.nih.gov/pubmed/37494662 http://dx.doi.org/10.18632/aging.204903 |
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