SF3B1 mutation–mediated sensitization to H3B-8800 splicing inhibitor in chronic lymphocytic leukemia

Splicing factor 3B subunit 1 (SF3B1) is involved in pre-mRNA branch site recognition and is the target of antitumor-splicing inhibitors. Mutations in SF3B1 are observed in 15% of patients with chronic lymphocytic leukemia (CLL) and are associated with poor prognosis, but their pathogenic mechanisms...

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Detalles Bibliográficos
Autores principales: López-Oreja, Irene, Gohr, André, Playa-Albinyana, Heribert, Giró, Ariadna, Arenas, Fabian, Higashi, Morihiro, Tripathi, Rupal, López-Guerra, Mònica, Irimia, Manuel, Aymerich, Marta, Valcárcel, Juan, Bonnal, Sophie, Colomer, Dolors
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Life Science Alliance LLC 2023
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10415613/
https://www.ncbi.nlm.nih.gov/pubmed/37562845
http://dx.doi.org/10.26508/lsa.202301955

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10415613/
https://www.ncbi.nlm.nih.gov/pubmed/37562845
http://dx.doi.org/10.26508/lsa.202301955

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