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Bioaccessibility and bioactive potential of different phytochemical classes from nutraceuticals and functional foods
Nutraceuticals and functional foods are composed of especially complex matrices, with polyphenols, carotenoids, minerals, and vitamins, among others, being the main classes of phytochemicals involved in their bioactivities. Despite their wide use, further investigations are needed to certify the pro...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2023
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10415696/ https://www.ncbi.nlm.nih.gov/pubmed/37575331 http://dx.doi.org/10.3389/fnut.2023.1184535 |
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author | Nicolescu, Alexandru Babotă, Mihai Barros, Lillian Rocchetti, Gabriele Lucini, Luigi Tanase, Corneliu Mocan, Andrei Bunea, Claudiu I. Crișan, Gianina |
author_facet | Nicolescu, Alexandru Babotă, Mihai Barros, Lillian Rocchetti, Gabriele Lucini, Luigi Tanase, Corneliu Mocan, Andrei Bunea, Claudiu I. Crișan, Gianina |
author_sort | Nicolescu, Alexandru |
collection | PubMed |
description | Nutraceuticals and functional foods are composed of especially complex matrices, with polyphenols, carotenoids, minerals, and vitamins, among others, being the main classes of phytochemicals involved in their bioactivities. Despite their wide use, further investigations are needed to certify the proper release of these phytochemicals into the gastrointestinal medium, where the bioaccessibility assay is one of the most frequently used method. The aim of this review was to gather and describe different methods that can be used to assess the bioaccessibility of nutraceuticals and functional foods, along with the most important factors that can impact this process. The link between simulated digestion testing of phytochemicals and their in vitro bioactivity is also discussed, with a special focus on the potential of developing nutraceuticals and functional foods from simple plant materials. The bioactive potential of certain classes of phytochemicals from nutraceuticals and functional foods is susceptible to different variations during the bioaccessibility assessment, with different factors contributing to this variability, namely the chemical composition and the nature of the matrix. Regardless of the high number of studies, the current methodology fails to assume correlations between bioaccessibility and bioactivity, and the findings of this review indicate a necessity for updated and standardized protocols. |
format | Online Article Text |
id | pubmed-10415696 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2023 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-104156962023-08-12 Bioaccessibility and bioactive potential of different phytochemical classes from nutraceuticals and functional foods Nicolescu, Alexandru Babotă, Mihai Barros, Lillian Rocchetti, Gabriele Lucini, Luigi Tanase, Corneliu Mocan, Andrei Bunea, Claudiu I. Crișan, Gianina Front Nutr Nutrition Nutraceuticals and functional foods are composed of especially complex matrices, with polyphenols, carotenoids, minerals, and vitamins, among others, being the main classes of phytochemicals involved in their bioactivities. Despite their wide use, further investigations are needed to certify the proper release of these phytochemicals into the gastrointestinal medium, where the bioaccessibility assay is one of the most frequently used method. The aim of this review was to gather and describe different methods that can be used to assess the bioaccessibility of nutraceuticals and functional foods, along with the most important factors that can impact this process. The link between simulated digestion testing of phytochemicals and their in vitro bioactivity is also discussed, with a special focus on the potential of developing nutraceuticals and functional foods from simple plant materials. The bioactive potential of certain classes of phytochemicals from nutraceuticals and functional foods is susceptible to different variations during the bioaccessibility assessment, with different factors contributing to this variability, namely the chemical composition and the nature of the matrix. Regardless of the high number of studies, the current methodology fails to assume correlations between bioaccessibility and bioactivity, and the findings of this review indicate a necessity for updated and standardized protocols. Frontiers Media S.A. 2023-07-27 /pmc/articles/PMC10415696/ /pubmed/37575331 http://dx.doi.org/10.3389/fnut.2023.1184535 Text en Copyright © 2023 Nicolescu, Babotă, Barros, Rocchetti, Lucini, Tanase, Mocan, Bunea and Crișan. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Nutrition Nicolescu, Alexandru Babotă, Mihai Barros, Lillian Rocchetti, Gabriele Lucini, Luigi Tanase, Corneliu Mocan, Andrei Bunea, Claudiu I. Crișan, Gianina Bioaccessibility and bioactive potential of different phytochemical classes from nutraceuticals and functional foods |
title | Bioaccessibility and bioactive potential of different phytochemical classes from nutraceuticals and functional foods |
title_full | Bioaccessibility and bioactive potential of different phytochemical classes from nutraceuticals and functional foods |
title_fullStr | Bioaccessibility and bioactive potential of different phytochemical classes from nutraceuticals and functional foods |
title_full_unstemmed | Bioaccessibility and bioactive potential of different phytochemical classes from nutraceuticals and functional foods |
title_short | Bioaccessibility and bioactive potential of different phytochemical classes from nutraceuticals and functional foods |
title_sort | bioaccessibility and bioactive potential of different phytochemical classes from nutraceuticals and functional foods |
topic | Nutrition |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10415696/ https://www.ncbi.nlm.nih.gov/pubmed/37575331 http://dx.doi.org/10.3389/fnut.2023.1184535 |
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