Pregnane X receptor activation remodels glucose metabolism to promote NAFLD development in obese mice

OBJECTIVE: Both obesity and exposure to chemicals may induce non-alcoholic fatty liver disease (NAFLD). Pregnane X Receptor (PXR) is a central target of metabolism disrupting chemicals and disturbs hepatic glucose and lipid metabolism. We hypothesized that the metabolic consequences of PXR activatio...

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Detalles Bibliográficos
Autores principales: Karpale, Mikko, Kummu, Outi, Kärkkäinen, Olli, Lehtonen, Marko, Näpänkangas, Juha, Herfurth, Uta M., Braeuning, Albert, Rysä, Jaana, Hakkola, Jukka
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2023
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10415798/
https://www.ncbi.nlm.nih.gov/pubmed/37467962
http://dx.doi.org/10.1016/j.molmet.2023.101779

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10415798/
https://www.ncbi.nlm.nih.gov/pubmed/37467962
http://dx.doi.org/10.1016/j.molmet.2023.101779

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