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Pregnane X receptor activation remodels glucose metabolism to promote NAFLD development in obese mice
OBJECTIVE: Both obesity and exposure to chemicals may induce non-alcoholic fatty liver disease (NAFLD). Pregnane X Receptor (PXR) is a central target of metabolism disrupting chemicals and disturbs hepatic glucose and lipid metabolism. We hypothesized that the metabolic consequences of PXR activatio...
Autores principales: | Karpale, Mikko, Kummu, Outi, Kärkkäinen, Olli, Lehtonen, Marko, Näpänkangas, Juha, Herfurth, Uta M., Braeuning, Albert, Rysä, Jaana, Hakkola, Jukka |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10415798/ https://www.ncbi.nlm.nih.gov/pubmed/37467962 http://dx.doi.org/10.1016/j.molmet.2023.101779 |
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