The prediction of Alzheimer’s disease through multi-trait genetic modeling

To better capture the polygenic architecture of Alzheimer’s disease (AD), we developed a joint genetic score, MetaGRS. We incorporated genetic variants for AD and 24 other traits from two independent cohorts, NACC (n = 3,174, training set) and UPitt (n = 2,053, validation set). One standard deviatio...

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Detalles Bibliográficos
Autores principales: Clark, Kaylyn, Fu, Wei, Liu, Chia-Lun, Ho, Pei-Chuan, Wang, Hui, Lee, Wan-Ping, Chou, Shin-Yi, Wang, Li-San, Tzeng, Jung-Ying
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2023
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10416111/
https://www.ncbi.nlm.nih.gov/pubmed/37577355
http://dx.doi.org/10.3389/fnagi.2023.1168638

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10416111/
https://www.ncbi.nlm.nih.gov/pubmed/37577355
http://dx.doi.org/10.3389/fnagi.2023.1168638

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