Acid ceramidase gene therapy ameliorates pulmonary arterial hypertension with right heart dysfunction

BACKGROUND: Up-regulation of ceramides in pulmonary hypertension (PH), contributing to perturbations in sphingolipid homeostasis and the transition of cells to a senescence state. We assessed the safety, feasibility, and efficiency of acid ceramidase gene transfer in a rodent PH model. METHODS: A mo...

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Detalles Bibliográficos
Autores principales: Katz, Michael G., Hadas, Yoav, Vincek, Adam, Freage-Kahn, Lina, Shtraizent, Nataly, Madjarov, Jeko M., Pastuszko, Peter, Eliyahu, Efrat
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10416391/
https://www.ncbi.nlm.nih.gov/pubmed/37568148
http://dx.doi.org/10.1186/s12931-023-02487-2

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10416391/
https://www.ncbi.nlm.nih.gov/pubmed/37568148
http://dx.doi.org/10.1186/s12931-023-02487-2

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