Cargando…

Acid ceramidase gene therapy ameliorates pulmonary arterial hypertension with right heart dysfunction

BACKGROUND: Up-regulation of ceramides in pulmonary hypertension (PH), contributing to perturbations in sphingolipid homeostasis and the transition of cells to a senescence state. We assessed the safety, feasibility, and efficiency of acid ceramidase gene transfer in a rodent PH model. METHODS: A mo...

Descripción completa

Detalles Bibliográficos
Autores principales:	Katz, Michael G., Hadas, Yoav, Vincek, Adam, Freage-Kahn, Lina, Shtraizent, Nataly, Madjarov, Jeko M., Pastuszko, Peter, Eliyahu, Efrat
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	BioMed Central 2023
Materias:	Research
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10416391/ https://www.ncbi.nlm.nih.gov/pubmed/37568148 http://dx.doi.org/10.1186/s12931-023-02487-2

Ejemplares similares

Chronic thoracic pain after cardiac surgery: role of inflammation and biomechanical sternal stability
por: Madjarov, Jeko M., et al.
Publicado: (2023)

MPI depletion enhances O-GlcNAcylation of p53 and suppresses the Warburg effect
por: Shtraizent, Nataly, et al.
Publicado: (2017)

Proximal aortic arch re-dilatation after external aortic wrapping
por: Madjarov, Jeko M., et al.
Publicado: (2021)

Advantages of intraoperative implantation of Impella 5.5 SmartAssist in the Management of Acute Post-Infarction Ventricular Septal Defect with cardiogenic shock
por: Madjarov, Jeko M., et al.
Publicado: (2021)

Case report: Re-emerging significance of surgical embolectomy in pulmonary embolism
por: Kay, Dana F., et al.
Publicado: (2018)

Targeting acid ceramidase ameliorates fibrosis in mouse models of non-alcoholic steatohepatitis
por: Yu, Amy, et al.
Publicado: (2022)

Surgical intervention in a complicated persistent chyle leak
por: Tenny, Bradley Curtis, et al.
Publicado: (2017)

Early Surgical Reconstruction of Sternum with Longitudinal Rigid Polymer Plating after Acute Chest Trauma
por: Madjarov, Jeko M., et al.
Publicado: (2018)

Acid Ceramidase Maintains the Chondrogenic Phenotype of Expanded Primary Chondrocytes and Improves the Chondrogenic Differentiation of Bone Marrow-Derived Mesenchymal Stem Cells
por: Simonaro, Calogera M., et al.
Publicado: (2013)

Structure of a human intramembrane ceramidase explains enzymatic dysfunction found in leukodystrophy
por: Vasiliauskaité-Brooks, Ieva, et al.
Publicado: (2018)

CDase is a pan-ceramidase in Drosophila
por: Yuan, Changqing, et al.
Publicado: (2011)

Structural basis for the activation of acid ceramidase
por: Gebai, Ahmad, et al.
Publicado: (2018)

Adiponectin serenades ceramidase to improve metabolism
por: Reibe-Pal, Saskia, et al.
Publicado: (2017)

Presence of Ceramidase Activity in Electronegative LDL
por: Puig, Núria, et al.
Publicado: (2022)

Inhibition of acid ceramidase elicits mitochondrial dysfunction and oxidative stress in pancreatic cancer cells
por: Taniai, Tomohiko, et al.
Publicado: (2021)

Single-stage hybrid repair of a ruptured Kommerell diverticulum associated with dextrorotation, bovine arch, and bicuspid aortic valve
por: Madjarov, Jeko M., et al.
Publicado: (2019)

Hot Spot Mutation in TP53 (R248Q) Causes Oncogenic Gain-of-Function Phenotypes in a Breast Cancer Cell Line Derived from an African American patient
por: Shtraizent, Nataly, et al.
Publicado: (2015)

Acid ceramidase confers radioresistance to glioblastoma cells
por: Doan, Ninh B., et al.
Publicado: (2017)

Role of Ceramidases in Sphingolipid Metabolism and Human Diseases
por: Parveen, Farzana, et al.
Publicado: (2019)

Acid ceramidase promotes senescent cell survival
por: Munk, Rachel, et al.
Publicado: (2021)

Revision of subcutaneous implantable cardioverter defibrillator to intermuscular pocket to prevent inappropriate shocks
por: Madjarov, Jeko M., et al.
Publicado: (2020)

Acid Ceramidase Rescues Cystic Fibrosis Mice from Pulmonary Infections
por: Becker, Katrin Anne, et al.
Publicado: (2021)

Impedimetric Detection of Mutant p53 Biomarker-Driven Metastatic Breast Cancers under Hyposmotic Pressure
por: Shi, Menglu, et al.
Publicado: (2014)

Acid ceramidase deficiency: Farber disease and SMA-PME
por: Yu, Fabian P. S., et al.
Publicado: (2018)

Targeting Acid Ceramidase to Improve the Radiosensitivity of Rectal Cancer
por: Clifford, Rachael E., et al.
Publicado: (2020)

Neutral ceramidase deficiency protects against cisplatin-induced acute kidney injury
por: Sears, Sophia M., et al.
Publicado: (2022)

AKT as a key target for growth promoting functions of neutral ceramidase in colon cancer cells
por: Coant, Nicolas, et al.
Publicado: (2018)

Potent Inhibition of Acid Ceramidase by Novel B-13 Analogues
por: Proksch, Denny, et al.
Publicado: (2011)

Deletion of MCP-1 Impedes Pathogenesis of Acid Ceramidase Deficiency
por: Yu, Fabian P. S., et al.
Publicado: (2018)

Recombinant Acid Ceramidase Reduces Inflammation and Infection in Cystic Fibrosis
por: Gardner, Aaron I., et al.
Publicado: (2020)

Neutral ceramidase is a marker for cognitive performance in rats and monkeys
por: Kalinichenko, Liubov S., et al.
Publicado: (2020)

Alkaline ceramidase 2 and its bioactive product sphingosine are novel regulators of the DNA damage response
por: Xu, Ruijuan, et al.
Publicado: (2016)

Right Ventricular Dysfunction in Lupus Patients With Pulmonary Hypertension
por: Barberato, Silvio Henrique
Publicado: (2018)

How to Determine Right Ventricular Dysfunction in Pulmonary Hypertension
por: Kim, Hyung Yoon, et al.
Publicado: (2021)

Benzoxazolone Carboxamides: Potent and Systemically Active Inhibitors of Intracellular Acid Ceramidase**
por: Pizzirani, Daniela, et al.
Publicado: (2015)

Genetic Variation in Acid Ceramidase Predicts Non-completion of an Exercise Intervention
por: Lewis, Lauren S., et al.
Publicado: (2018)

Acid ceramidase is upregulated in AML and represents a novel therapeutic target
por: Tan, Su-Fern, et al.
Publicado: (2016)

Acid ceramidase is a novel drug target for pediatric brain tumors
por: Doan, Ninh B., et al.
Publicado: (2017)

Anticancer actions of lysosomally targeted inhibitor, LCL521, of acid ceramidase
por: Bai, Aiping, et al.
Publicado: (2017)

Elusive Roles of the Different Ceramidases in Human Health, Pathophysiology, and Tissue Regeneration
por: Duarte, Carolina, et al.
Publicado: (2020)

Cannot write session to /tmp/vufind_sessions/sess_p3hajaqeq3llehehinj4397bu6