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Fance deficiency inhibits primordial germ cell proliferation associated with transcription–replication conflicts accumulate and DNA repair defects

Fanconi anemia (FA) gene mutations are critical components in the genetic etiology of premature ovarian insufficiency (POI). Fance(−/−) mice detected meiotic arrest of primordial germ cells (PGCs) as early as embryonic day (E) 13.5 and exhibited decreased ovarian reserve after birth. However, the me...

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Detalles Bibliográficos
Autores principales: Zhou, Zhixian, Yin, Huan, Suye, Suye, Ren, Zhen, Yan, Lei, Shi, Liye, Fu, Chun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2023
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10416540/
https://www.ncbi.nlm.nih.gov/pubmed/37563658
http://dx.doi.org/10.1186/s13048-023-01252-9