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Fance deficiency inhibits primordial germ cell proliferation associated with transcription–replication conflicts accumulate and DNA repair defects
Fanconi anemia (FA) gene mutations are critical components in the genetic etiology of premature ovarian insufficiency (POI). Fance(−/−) mice detected meiotic arrest of primordial germ cells (PGCs) as early as embryonic day (E) 13.5 and exhibited decreased ovarian reserve after birth. However, the me...
Autores principales: | Zhou, Zhixian, Yin, Huan, Suye, Suye, Ren, Zhen, Yan, Lei, Shi, Liye, Fu, Chun |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2023
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10416540/ https://www.ncbi.nlm.nih.gov/pubmed/37563658 http://dx.doi.org/10.1186/s13048-023-01252-9 |
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